Browse result page of PRRDB 2.0

PRRID	Name of Ligand	Source of ligand	Sequence of Ligand	Length of Ligand	Type of Ligand	Occurence	Role of Ligand	Name of Receptor	Type of Reeptor	Source of the Receptor	Localization	Domain	Sequence of Receptor	Swiss prot ID	Length of receptor	Function of Receptor	Assay used	PMID	Year of publication	Pubchem assay
PRRID_1218	CpG-ODN Click for more detail	Bacteria	NA	NA	Nucleic Acid	Synthetic	induction of the antiviral protein Mx	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Atlantic salmon (Salmo salar)	muscle, head kidney, liver, gut, heart, spleen and gill	NA	A8SZH4.fasta	A8SZH4	1074	strong induction of IL-1b and IFN-a1	Real-time PCR	24736205	2014	Pubchem_assay
PRRID_1218	CpG-ODN Click for more detail	Bacteria	NA	NA	Nucleic Acid	Synthetic	induction of the antiviral protein Mx	Toll-like receptor 9 (TLR9)	Toll-like receptor (TLR)	Atlantic salmon (Salmo salar)	muscle, head kidney, liver, gut, heart, spleen and gill	NA	A8SZH4.fasta	A8SZH4	1074	strong induction of IL-1b and IFN-a1	Real-time PCR	24736205	2014	Pubchem_assay
PRRID_1293	Flagellin Click for more detail	Vibrio anguillarum (Bacteria)	MAVNVNTNVSAMTAQRYLNSASNAQQLSMERLSSGFKINNAKDDAAGLQISNRLNVQSRGLDVAVRNANDGISIAQTAEGAMNETTNILQRMRDLSLQSSNGSNSKADRVAIQEEITALNDELNRIAETTSFGGNKLLNGTFETKSFQIGADNGEAVMLSLNNMRSDNAMMGGKSYQAANGQDKDWTVKAGANDLTITLTDKRTGEQTINLSAKDGDDIEELATYINGQTDMLKASVDDEGKLQIFTDSNRIDGVATFGGSLAGELSFQAAKDVTVDTIDVTSVGGSQESVAIVDAALQFVDSHRAQLGAFQNRFNHAINNLDNINENVNASKSRIKDTDFAKETTALTKSQILSQASSSVLAQAKQAPNAALGLLG	377	Protein	Natural	Flagellin induced expres- sion of inflammatory cytokines	Toll-like receptor 5M (TLR5M)	Toll-like receptor (TLR)	Atlantic salmon (Salmo salar)	muscle, head kidney, liver, gut, heart, spleen and gill	NA	NA	NA	NA	it could stimulate NF-jB activation in vitro after exposure to Vibrio anguillarum-derived flagellin suggesting that both forms could sense flagellin	Real-time PCR	24736205	2014	NA
PRRID_1293	Flagellin Click for more detail	Vibrio anguillarum (Bacteria)	MAVNVNTNVSAMTAQRYLNSASNAQQLSMERLSSGFKINNAKDDAAGLQISNRLNVQSRGLDVAVRNANDGISIAQTAEGAMNETTNILQRMRDLSLQSSNGSNSKADRVAIQEEITALNDELNRIAETTSFGGNKLLNGTFETKSFQIGADNGEAVMLSLNNMRSDNAMMGGKSYQAANGQDKDWTVKAGANDLTITLTDKRTGEQTINLSAKDGDDIEELATYINGQTDMLKASVDDEGKLQIFTDSNRIDGVATFGGSLAGELSFQAAKDVTVDTIDVTSVGGSQESVAIVDAALQFVDSHRAQLGAFQNRFNHAINNLDNINENVNASKSRIKDTDFAKETTALTKSQILSQASSSVLAQAKQAPNAALGLLG	377	Protein	Natural	Flagellin induced expres- sion of inflammatory cytokines	Toll-like receptor 5M (TLR5M)	Toll-like receptor (TLR)	Atlantic salmon (Salmo salar)	muscle, head kidney, liver, gut, heart, spleen and gill	NA	NA	NA	NA	it could stimulate NF-jB activation in vitro after exposure to Vibrio anguillarum-derived flagellin suggesting that both forms could sense flagellin	Real-time PCR	24736205	2014	NA
PRRID_1294	Flagellin Click for more detail	Vibrio anguillarum (Bacteria)	MAVNVNTNVSAMTAQRYLNSASNAQQLSMERLSSGFKINNAKDDAAGLQISNRLNVQSRGLDVAVRNANDGISIAQTAEGAMNETTNILQRMRDLSLQSSNGSNSKADRVAIQEEITALNDELNRIAETTSFGGNKLLNGTFETKSFQIGADNGEAVMLSLNNMRSDNAMMGGKSYQAANGQDKDWTVKAGANDLTITLTDKRTGEQTINLSAKDGDDIEELATYINGQTDMLKASVDDEGKLQIFTDSNRIDGVATFGGSLAGELSFQAAKDVTVDTIDVTSVGGSQESVAIVDAALQFVDSHRAQLGAFQNRFNHAINNLDNINENVNASKSRIKDTDFAKETTALTKSQILSQASSSVLAQAKQAPNAALGLLG	377	Protein	Natural	Flagellin induced expres- sion of inflammatory cytokines	Toll-like receptor 5s (TLR5s)	Toll-like receptor (TLR)	Atlantic salmon (Salmo salar)	predominanlty in liver	NA	NA	NA	NA	it could stimulate NF-jB activation in vitro after exposure to Vibrio anguillarum-derived flagellin suggesting that both forms could sense flagellin	Real-time PCR	24736205	2014	NA
PRRID_1294	Flagellin Click for more detail	Vibrio anguillarum (Bacteria)	MAVNVNTNVSAMTAQRYLNSASNAQQLSMERLSSGFKINNAKDDAAGLQISNRLNVQSRGLDVAVRNANDGISIAQTAEGAMNETTNILQRMRDLSLQSSNGSNSKADRVAIQEEITALNDELNRIAETTSFGGNKLLNGTFETKSFQIGADNGEAVMLSLNNMRSDNAMMGGKSYQAANGQDKDWTVKAGANDLTITLTDKRTGEQTINLSAKDGDDIEELATYINGQTDMLKASVDDEGKLQIFTDSNRIDGVATFGGSLAGELSFQAAKDVTVDTIDVTSVGGSQESVAIVDAALQFVDSHRAQLGAFQNRFNHAINNLDNINENVNASKSRIKDTDFAKETTALTKSQILSQASSSVLAQAKQAPNAALGLLG	377	Protein	Natural	Flagellin induced expres- sion of inflammatory cytokines	Toll-like receptor 5s (TLR5s)	Toll-like receptor (TLR)	Atlantic salmon (Salmo salar)	predominanlty in liver	NA	NA	NA	NA	it could stimulate NF-jB activation in vitro after exposure to Vibrio anguillarum-derived flagellin suggesting that both forms could sense flagellin	Real-time PCR	24736205	2014	NA
PRRID_1457	Long ds RNA Click for more detail	fugu (Takifugu rubripes) (others)	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 22 (TLR22)	Toll-like receptor (TLR)	Atlantic salmon (Salmo salar)	NA	NA	Q2A132.fasta	Q2A132	971	participate together with TLR3 in type I interferon production	Real-time PCR	24736205	2014	Pubchem_assay
PRRID_1457	Long ds RNA Click for more detail	fugu (Takifugu rubripes) (others)	NA	NA	Nucleic Acid	Natural	triggers immune responses	Toll-like receptor 22 (TLR22)	Toll-like receptor (TLR)	Atlantic salmon (Salmo salar)	NA	NA	Q2A132.fasta	Q2A132	971	participate together with TLR3 in type I interferon production	Real-time PCR	24736205	2014	Pubchem_assay
PRRID_1502	NA Click for more detail	NA	NA	NA	NA	Natural	NA	Toll-like receptor 1 (TLR1)	Toll-like receptor (TLR)	Atlantic salmon (Salmo salar)	muscle, head kidney, liver, gut, heart, spleen and gill	NA	NA	NA	NA	NA	Real-time PCR	24736205	2014	NA
PRRID_1502	NA Click for more detail	NA	NA	NA	NA	Natural	NA	Toll-like receptor 1 (TLR1)	Toll-like receptor (TLR)	Atlantic salmon (Salmo salar)	muscle, head kidney, liver, gut, heart, spleen and gill	NA	NA	NA	NA	NA	Real-time PCR	24736205	2014	NA
PRRID_1503	NA Click for more detail	NA	NA	NA	NA	Natural	NA	Toll-like receptor 13 (TLR13)	Toll-like receptor (TLR)	Atlantic salmon (Salmo salar)	muscle, head kidney, liver, gut, heart, spleen and gill	NA	B5X405.fasta	B5X405	962	NA	Real-time PCR	24736205	2014	Pubchem_assay
PRRID_1503	NA Click for more detail	NA	NA	NA	NA	Natural	NA	Toll-like receptor 13 (TLR13)	Toll-like receptor (TLR)	Atlantic salmon (Salmo salar)	muscle, head kidney, liver, gut, heart, spleen and gill	NA	B5X405.fasta	B5X405	962	NA	Real-time PCR	24736205	2014	Pubchem_assay
PRRID_1586	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	poly I:C expressed significantly higher levels of IFN-a1 and IFN-c and Mx	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Atlantic salmon (Salmo salar)	muscle, head kidney, liver, gut, heart, spleen and gill	NA	M1ZMQ4.fasta	M1ZMQ4	913	play a role in antiviral response in salmon	Real-time PCR	24736205	2014	Pubchem_assay
PRRID_1586	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	poly I:C expressed significantly higher levels of IFN-a1 and IFN-c and Mx	Toll-like receptor 3 (TLR3)	Toll-like receptor (TLR)	Atlantic salmon (Salmo salar)	muscle, head kidney, liver, gut, heart, spleen and gill	NA	M1ZMQ4.fasta	M1ZMQ4	913	play a role in antiviral response in salmon	Real-time PCR	24736205	2014	Pubchem_assay
PRRID_1587	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	poly I:C expressed significantly higher levels of IFN-a1 and IFN-c and Mx	Toll-like receptor 22a1 (TLR22a1)	Toll-like receptor (TLR)	Atlantic salmon (Salmo salar)	muscle, head kidney, liver, gut, heart, spleen and gill	NA	NA	NA	NA	paralleled TLR3 up-regulation in virus- infected fish	Real-time PCR	24736205	2014	NA
PRRID_1587	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	poly I:C expressed significantly higher levels of IFN-a1 and IFN-c and Mx	Toll-like receptor 22a1 (TLR22a1)	Toll-like receptor (TLR)	Atlantic salmon (Salmo salar)	muscle, head kidney, liver, gut, heart, spleen and gill	NA	NA	NA	NA	paralleled TLR3 up-regulation in virus- infected fish	Real-time PCR	24736205	2014	NA
PRRID_1588	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	poly I:C expressed significantly higher levels of IFN-a1 and IFN-c and Mx	Toll-like receptor 22a2 (TLR22a2)	Toll-like receptor (TLR)	Atlantic salmon (Salmo salar)	muscle, head kidney, liver, gut, heart, spleen and gill	NA	B5BM14.fasta	B5BM14	925	paralleled TLR3 up-regulation in virus- infected fish	Real-time PCR	24736205	2014	Pubchem_assay
PRRID_1588	polyinosinic-polycytidylic acid [poly(I:C)] Click for more detail	NA	C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O	NA	Nucleic Acid	Synthetic	poly I:C expressed significantly higher levels of IFN-a1 and IFN-c and Mx	Toll-like receptor 22a2 (TLR22a2)	Toll-like receptor (TLR)	Atlantic salmon (Salmo salar)	muscle, head kidney, liver, gut, heart, spleen and gill	NA	B5BM14.fasta	B5BM14	925	paralleled TLR3 up-regulation in virus- infected fish	Real-time PCR	24736205	2014	Pubchem_assay
PRRID_1657	type I interferons Click for more detail	Host (Endogenous) (others)	MYTVQSWTCICLIICSMQSVCHCCDWIRHHYGHLSSEYLSLLDQMGGDITKQDAPVFFPTSLYRHIDDAEVEDQVRFLKETIYQITKLFDGNMKSVTWDKKKLDDFLNILERQLENLKSCVSPAMKPEKRLKRYFKKLNKNVLRKMNYSAQAWELIRKETKRHLQRLDILAAQMY	175	Protein	Natural	induces TLR7 and TLR 8 in salmon	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Atlantic salmon (Salmo salar)	highest expression in spleen and head kidney and relatively low expression in muscle, liver, gut, heart and gill	NA	S0F0X6.fasta	S0F0X6	1063	antiviral response in salmon	Real-time PCR	24736205	2014	Pubchem_assay
PRRID_1657	type I interferons Click for more detail	Host (Endogenous) (others)	MYTVQSWTCICLIICSMQSVCHCCDWIRHHYGHLSSEYLSLLDQMGGDITKQDAPVFFPTSLYRHIDDAEVEDQVRFLKETIYQITKLFDGNMKSVTWDKKKLDDFLNILERQLENLKSCVSPAMKPEKRLKRYFKKLNKNVLRKMNYSAQAWELIRKETKRHLQRLDILAAQMY	175	Protein	Natural	induces TLR7 and TLR 8 in salmon	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Atlantic salmon (Salmo salar)	highest expression in spleen and head kidney and relatively low expression in muscle, liver, gut, heart and gill	NA	S0F0X6.fasta	S0F0X6	1063	antiviral response in salmon	Real-time PCR	24736205	2014	Pubchem_assay
PRRID_1658	type I interferons Click for more detail	Host (Endogenous) (others)	MYTVQSWTCICLIICSMQSVCHCCDWIRHHYGHLSSEYLSLLDQMGGDITKQDAPVFFPTSLYRHIDDAEVEDQVRFLKETIYQITKLFDGNMKSVTWDKKKLDDFLNILERQLENLKSCVSPAMKPEKRLKRYFKKLNKNVLRKMNYSAQAWELIRKETKRHLQRLDILAAQMY	175	Protein	Natural	induces TLR7 and TLR 8 in salmon	Toll-like receptor 8a1 (TLR8a1)	Toll-like receptor (TLR)	Atlantic salmon (Salmo salar)	highest expression in spleen and head kidney and relatively low expression in muscle, liver, gut, heart and gill	NA	NA	NA	NA	antiviral response in salmon	Real-time PCR	24736205	2014	NA
PRRID_1658	type I interferons Click for more detail	Host (Endogenous) (others)	MYTVQSWTCICLIICSMQSVCHCCDWIRHHYGHLSSEYLSLLDQMGGDITKQDAPVFFPTSLYRHIDDAEVEDQVRFLKETIYQITKLFDGNMKSVTWDKKKLDDFLNILERQLENLKSCVSPAMKPEKRLKRYFKKLNKNVLRKMNYSAQAWELIRKETKRHLQRLDILAAQMY	175	Protein	Natural	induces TLR7 and TLR 8 in salmon	Toll-like receptor 8a1 (TLR8a1)	Toll-like receptor (TLR)	Atlantic salmon (Salmo salar)	highest expression in spleen and head kidney and relatively low expression in muscle, liver, gut, heart and gill	NA	NA	NA	NA	antiviral response in salmon	Real-time PCR	24736205	2014	NA
PRRID_1659	type I interferons Click for more detail	Host (Endogenous) (others)	MYTVQSWTCICLIICSMQSVCHCCDWIRHHYGHLSSEYLSLLDQMGGDITKQDAPVFFPTSLYRHIDDAEVEDQVRFLKETIYQITKLFDGNMKSVTWDKKKLDDFLNILERQLENLKSCVSPAMKPEKRLKRYFKKLNKNVLRKMNYSAQAWELIRKETKRHLQRLDILAAQMY	175	Protein	Natural	induces TLR7 and TLR 8 in salmon	Toll-like receptor 8a2 (TLR8a2)	Toll-like receptor (TLR)	Atlantic salmon (Salmo salar)	highest expression in spleen and head kidney and relatively low expression in muscle, liver, gut, heart and gill	NA	S0F0N4.fasta	S0F0N4	1035	antiviral response in salmon	Real-time PCR	24736205	2014	Pubchem_assay
PRRID_1659	type I interferons Click for more detail	Host (Endogenous) (others)	MYTVQSWTCICLIICSMQSVCHCCDWIRHHYGHLSSEYLSLLDQMGGDITKQDAPVFFPTSLYRHIDDAEVEDQVRFLKETIYQITKLFDGNMKSVTWDKKKLDDFLNILERQLENLKSCVSPAMKPEKRLKRYFKKLNKNVLRKMNYSAQAWELIRKETKRHLQRLDILAAQMY	175	Protein	Natural	induces TLR7 and TLR 8 in salmon	Toll-like receptor 8a2 (TLR8a2)	Toll-like receptor (TLR)	Atlantic salmon (Salmo salar)	highest expression in spleen and head kidney and relatively low expression in muscle, liver, gut, heart and gill	NA	S0F0N4.fasta	S0F0N4	1035	antiviral response in salmon	Real-time PCR	24736205	2014	Pubchem_assay
PRRID_1660	type I interferons Click for more detail	Host (Endogenous) (others)	MYTVQSWTCICLIICSMQSVCHCCDWIRHHYGHLSSEYLSLLDQMGGDITKQDAPVFFPTSLYRHIDDAEVEDQVRFLKETIYQITKLFDGNMKSVTWDKKKLDDFLNILERQLENLKSCVSPAMKPEKRLKRYFKKLNKNVLRKMNYSAQAWELIRKETKRHLQRLDILAAQMY	175	Protein	Natural	induces TLR7 and TLR 8 in salmon	Toll-like receptor 8b1 (TLR8b1)	Toll-like receptor (TLR)	Atlantic salmon (Salmo salar)	highest expression in spleen and head kidney and relatively low expression in muscle, liver, gut, heart and gill	NA	S0F1A6.fasta	S0F1A6	1034	antiviral response in salmon	Real-time PCR	24736205	2014	Pubchem_assay
PRRID_1660	type I interferons Click for more detail	Host (Endogenous) (others)	MYTVQSWTCICLIICSMQSVCHCCDWIRHHYGHLSSEYLSLLDQMGGDITKQDAPVFFPTSLYRHIDDAEVEDQVRFLKETIYQITKLFDGNMKSVTWDKKKLDDFLNILERQLENLKSCVSPAMKPEKRLKRYFKKLNKNVLRKMNYSAQAWELIRKETKRHLQRLDILAAQMY	175	Protein	Natural	induces TLR7 and TLR 8 in salmon	Toll-like receptor 8b1 (TLR8b1)	Toll-like receptor (TLR)	Atlantic salmon (Salmo salar)	highest expression in spleen and head kidney and relatively low expression in muscle, liver, gut, heart and gill	NA	S0F1A6.fasta	S0F1A6	1034	antiviral response in salmon	Real-time PCR	24736205	2014	Pubchem_assay
PRRID_1661	type I interferons Click for more detail	Host (Endogenous) (others)	MYTVQSWTCICLIICSMQSVCHCCDWIRHHYGHLSSEYLSLLDQMGGDITKQDAPVFFPTSLYRHIDDAEVEDQVRFLKETIYQITKLFDGNMKSVTWDKKKLDDFLNILERQLENLKSCVSPAMKPEKRLKRYFKKLNKNVLRKMNYSAQAWELIRKETKRHLQRLDILAAQMY	175	Protein	Natural	induces TLR7 and TLR 8 in salmon	Toll-like receptor 8b2 (TLR8b2)	Toll-like receptor (TLR)	Atlantic salmon (Salmo salar)	highest expression in spleen and head kidney and relatively low expression in muscle, liver, gut, heart and gill	NA	S0F1D1.fasta	S0F1D1	1036	antiviral response in salmon	Real-time PCR	24736205	2014	Pubchem_assay
PRRID_1661	type I interferons Click for more detail	Host (Endogenous) (others)	MYTVQSWTCICLIICSMQSVCHCCDWIRHHYGHLSSEYLSLLDQMGGDITKQDAPVFFPTSLYRHIDDAEVEDQVRFLKETIYQITKLFDGNMKSVTWDKKKLDDFLNILERQLENLKSCVSPAMKPEKRLKRYFKKLNKNVLRKMNYSAQAWELIRKETKRHLQRLDILAAQMY	175	Protein	Natural	induces TLR7 and TLR 8 in salmon	Toll-like receptor 8b2 (TLR8b2)	Toll-like receptor (TLR)	Atlantic salmon (Salmo salar)	highest expression in spleen and head kidney and relatively low expression in muscle, liver, gut, heart and gill	NA	S0F1D1.fasta	S0F1D1	1036	antiviral response in salmon	Real-time PCR	24736205	2014	Pubchem_assay